This course provides an overview of the synergistic interactions of humans, their diets, and disease from prehistoric through contemporary populations. We will explore the causes and consequences of major social transformations, including the shift from nomadic to sedentary life, animal and plant domestication, urbanism, and globalism through historical, bioarchaeological, epidemiological and anthropological lenses. We will learn the methods by which researchers reconstruct patterns of diet, disease and residential mobility in ancient populations, and how these ancient patterns compare and contrast to those in modern contexts.