Introduction to fundamental concepts in bioengineering with primary emphasis on understanding details of biomolecular structures integrated with molecular modeling, simulation, and visualization techniques. The course will introduce structural details of various biomolecules (proteins, nucleic-acids, sugars, and lipids), followed by concepts in thermodynamics and physical chemistry (such as intermolecular forces, energy, entropy, chemical potential, and Boltzmann's distribution), the applications of which will be discussed in the context of drug-receptor interactions, molecular recognition, biomolecular folding, enzyme catalysis, allosteric communication, diffusion, and transport. The laboratory will include training and learning about advanced simulation and visualization software engines.