The immunology of blood, including blood group systems and the critical role they play in safe transfusion medicine. Additional topics include blood collection, component use, transfusion reactions, and transfusion-transmitted infections.

Use of body fluids to assess specific disease states including the pathophysiology of the disease, pre-analytical issues, analytical methodologies, and instrumentation. Topics include the biochemistry of analytes (amino acids, proteins, enzymes, tumor markers, non-protein nitrogen metabolites, carbohydrates, lipids, electrolytes, blood gases, etc.), clinical endocrinology, toxicology and therapeutic drug monitoring.

Measurement of blood analytes such as proteins, glucose, electrolytes, and cholesterol, etc. Screening for drugs in urine and evaluation of clinical significance in human specimens. Principles of spectrometry, immunoassay, point-of-care testing, chromatography, mass spectrometry, electrophoresis, automation, and ion selective electrodes, with emphasis on instrumentation, quality control, and pre-analytical and analytical issues. Special fee.

Principles and mechanisms of disease at the cellular and tissue levels, including responses to cell injury, death and adaptation, inflammation, circulatory disturbances, disorders of the immune system, and neoplasia. ANSC 511 and ANSC 512, or BMS 507 and BMS 508 recommended.