Second course in design of experiments, with applications in quality improvement and industrial manufacturing, engineering research and development, research in physical and biological sciences. Covers experimental design strategies and issues that are often encountered in practice complete and incomplete blocking, partially balanced incomplete blocking (PBIB), partial confounding, intra and inter block information, split plotting and strip plotting, repeated measures, crossover designs, Latin squares and rectangles, Youden squares, crossed and nested treatment structures, variance components, mixed effects models, analysis of covariance, optimizations, space filling designs, and modern screening design strategies.