The immunology of blood, including blood group systems and the critical role they play in safe transfusion medicine. Additional topics include blood collection, component use, transfusion reactions, and transfusion-transmitted infections.

Use of body fluids to assess specific disease states including the pathophysiology of the disease, pre-analytical issues, analytical methodologies, and instrumentation. Topics include the biochemistry of analytes (amino acids, proteins, enzymes, tumor markers, non-protein nitrogen metabolites, carbohydrates, lipids, electrolytes, blood gases, etc.), clinical endocrinology, toxicology and therapeutic drug monitoring. Prereq: BMCB 658 and BMCB 659; BIOL 528, or equivalents.

Measurement of blood analytes such as proteins, glucose, electrolytes, and cholesterol, etc. Screening for drugs in urine and evaluation of clinical significance in human specimens. Principles of spectrometry, immunoassay, point-of-care testing, chromatography, mass spectrometry, electrophoresis, automation, and ion selective electrodes, with emphasis on instrumentation, quality control, and pre-analytical and analytical issues. Special fee.

Structure and function of vertebrate endocrine systems through the lens of physiology, biochemistry, and cell and molecular biology, with special reference to mammals. Current investigations of the body?s major endocrine glands, such as the brain, thyroid, pancreas, adrenals and gonads, as regulators and integrators of biological systems. BMCB 605 recommended. Prereq: BMCB 658 or BMCB 751.