First course in design of experiments with applications to quality improvement in industrial manufacturing, engineering research and development, or research in physical and biological sciences. Experimental factor identification, statistical analysis and modeling of experimental results, randomization and blocking, full factorial designs, random and mixed effects models, replication and sub-sampling strategies, fractional factorial designs, response surface methods, mixture designs, and screening designs. Focuses on various treatment structures for designed experimentation and the associated statistical analyses. Use of statistical software. Students must have completed an introductory statistics course.