Cannabis (marijuana) is listed on Schedule I of the Controlled Substances Act, and the possession, sale, and use of marijuana remains unlawful at the federal level. Meanwhile, cannabis legalization is sweeping the nation on a state-by-state basis. This federal and state divide presents unique challenges to businesses serving patients and consumers in the cannabis industry and the lawyers who advise them. This one-unit course will provide an overview of the current state of the cannabis industry, identify key legal and business challenges, and explore how lawyers are helping their clients address these challenges. The course will lay the groundwork for the type of issue spotting and creative thinking required to navigate the legal and business landscape of this emerging legal field.