This course is a survey of contemporary problems in microbal, plant, protozoan, and animal cell and biosystems signaling. Topics to be covered include: evolution of extracellular signals, receptor systems, and signal transduction pathways that govern cell proliferation, survival, and development; current technical approaches for discovery and characterization of signal transduction factor networks; corrupted signal transduction in disease; disease control or therapy. Students should have knowledge of cell biology, biochemistry, genetics and/or molecular biology.