Use of body fluids to assess specific disease states including the pathophysiology of the disease, pre-analytical issues, analytical methodologies, and instrumentation. Topics include the biochemistry of analytes (amino acids, proteins, enzymes, tumor markers, non-protein nitrogen metabolites, carbohydrates, lipids, electrolytes, blood gases, etc.), clinical endocrinology, toxicology and therapeutic drug monitoring. Prereq: BMCB 658 and BMCB 659; BIOL 528, or equivalents.